They practice traditional and herbal remedies as an alternative choice of treatment of malaria. Antimalarial activity of azafluorenone alkaloids from the. Research article antimalarial activity of some medicinal. Antimalarial activities of medicinal plants and herbal. In vitro and in vivo antimalarial activity of plants from. The present study was aimed at assessing the 30 antimalarial activity of crude extract isolated from various strains of actinobacteria living 31 endophytically in some malaysian medicinal plants. It is therefore of interest to screen medicinal plants from this region for an evaluation of in vitro antiplasmodial, in vivo antimalarial and toxicity tests. In vivo antimalarial activity of extracts of tanzanian medicinal plants. Briefly, varying concentrations 02 mgml in dmso of the extracts and fractions were produced. In vivo antimalarial activity, toxicity and phytochemical. Larvicidal, antipyretic and antiplasmodial activity of. Agbaje and onabanjo 1991 reported that aqueous extract of the plant e. Herein, 29 % of the extracts studied were active or moderately active in vitro. Phytochemical analysis and antimalarial activity aqueous.
Current statistics suggest that malaria kills between 2. Traditional medicine caters for about 80% of the health care needs of many rural populations around the world, especially in developing countries. Medicinal plants used in nigeria for malaria treatment are listed in table 1. Therefore in order to make health care accessible to 80% of rural people and now, increasingly urban people it is critical to sustain the medicinal plant resource base. Evaluation of the antiplasmodial activity of extracts of. Preliminary evaluation of selected medicinal plants for antiplasmodial activity 40 table 3.
In vivo antimalarial effect of three medicinal plants aqueous extracts ethanol extract 50% of 9 medicinal plants were tested in vitro for their antimalarial activities using cq sensitive isolate. In vitro antimalarial activity and cytotoxicity of some. Antiplasmodial, larvicidal, antipyretic activity, medicinal plants. Annona squamosa, custard apple, pharmacology, pharmacognosy, phytochemistry introduction in various indigenous and traditional sources of medicine plants have been extensively used for treatments.
When tested against two different strains of the parasite plasmodium falciparum 3d7 and dd2, 2 displayed ic50 values of 9. This study investigated the antimalarial activity, toxicity and the nature of major chemical classes present in four medicinal plants. Pdf in vitro antimalarial activity of medicinal plant. The present study has compiled and enlisted the antimalarial plants of northeast india, which would help future workers to find out the suitable antimalarial plants by thorough study. Workshop plantas medicinais e fitoterapeuticas nos tropicos.
Malaria is currently a public health concern in many countries in the world due to factors such as chemotherapy faced by resistance, poor hygienic conditions, poorly. Antimalarial activity and cytotoxicity of some south african medicinal plants and their active constituents. Therefore, the bioactive compounds of both plant extracts need to be investigated. Antimalarial activity of plant extracts either alone or in combination with chloroquine. Basir and others published antimalarial activity of selected malaysian medicinal plants find, read and cite all the research you need on researchgate. Antimalarial and antiplasmodial activity papaya leaves are made into tea as a treatment for malaria. During the span of the last 17 years, 175 antiplasmodial compounds were discovered from plants. The level of activity was discovered to be dose dependent, with the dose of 500 mg kg1 having the highest activity 75. Antimalarial activity of medicinal plants used in traditional medicine in s. Full length research paper evaluation of the antiplasmodial activity of extracts of plants used in traditional medicine in kenya sylvain beourou1,2,3. Antimalarial potential of plants used as chewing sticks. Several compounds have been obtained, mainly triterpenoids, isolated from m. The present study aimed to investigate antimalarial activities of a total of 27 medicinal plants and 5 herbal formulations used in thai traditional medicine against chloroquineresistant k1 and. Searching for natural antituberculars from mozambican.
Research article antimalarial activity of some medicinal sudanese plants intisar e. Antimalarial activity of some plants traditionally used in. Inspired by the discovery of the antimalarial drug artemisinin from a traditional chinese medicine tcm, a natural product library of 44 lindenanetype sesquiterpenoids was assessed for activities against the dd2 chloroquineresistant strain of the malaria parasite plasmodium falciparum. Products with antimalarial activity have been isolated from plants used against other parasites5,10 and some antimalarial natural products have shown good activity against a broad spectrum of parasites1. In our antimalarial drug discovery program, we have evaluated more than 2000 plant extracts against d6 and w2 strains of p. Medicinal plants for malaria treatment the search for new phytochemicals with antimalarial activity nigerian medicinal plants used for scientific authentication of antimalarial activities of nigerian medicinal plants isolated compounds characterized as antimalarials in nigerian medicinal plants 6. The present study aimed to investigate antimalarial activities of a total of 27 medicinal plants and 5 herbal formulations used in thai traditional medicine against chloroquineresistant k1 and chloroquinesensitive 3d7 p. In recent years, a large number of plants have been explored for their antimalarial potential. However, two others flavonoids isolated from the same sample did not show any activity, even though these compounds possessed prenylated substitution. Antimalarial compounds isolated from plants used in. In addition, plantderived compounds have played key roles in drug discovery. In continuation of our previous research on medicinal plants with antimalarial activity 1215, we conducted a series of quantitative hplc separations and studied the effect on hemozoin formation in order to explain the differences in antimalarial activity of a.
Except for artemisinin, none of the principles were near the effectiveness of the existing antimalarial drug quinine. To my delight and i am sure of anyone who picks up. Antimalarial activity of the extract was done by a standard 4day. Antimalarial activity and cytotoxicity of some south. A search of cuban medicinal species with antimalarial activity is being developed in our laboratory. The antimalarial potential of medicinal plants used for. Antiplasmodial activity of selected medicinal plants used. Active principles from these plants have been isolated and analyzed in detail. In an in vivo experiment, treatment of balbc mice with the aqueous balanite extract did not lead to eradication of the parasites, although a reduced parasitemia at day 12 p. Key words medicinal plants, traditional knowledge, complementary medicine, malaria, phytochemical screening, antimalarial compounds, alkaloids. Preliminary evaluation of selected medicinal plants for. This study was designed to evaluate the in vivo antimalarial activity and acute toxicity of selected medicinal plants commonly used in msambweni district, south coast of kenya for the treatment of malaria.
These compounds may contribute to the in vitro antimalarial activity due to their antioxidative properties. View enhanced pdf access article on wiley online library html view. Therefore, development of new potential antimalarial drugs is urgently required. The animals were randomly divided into 6 groups of 3 mice each. The choice of plants studied was based on the traditional use of the species ethnobotanic approach or on the traditional use and or proven antimalarial activity of plants and chemical constituents from the same genus chemosystematic approach. Evaluation of the cytotoxic activity of extracts from medicinal plants used for the treatment of malaria in kagera and lindi regions, tanzania.
Antimalarial activity and in vivo toxicity of selected. Only one third of the medicinal plants have been tested for their antimalarial activity, indicating that only a minority of the antimalarial plants has been validated. The potential of antimalarial compounds derived from. Pdf evaluation of the cytotoxic activity of extracts. Antimalarial activity of the root extract of euphorbia abyssinica. These results support the ethnomedicinal uses for these plants as complementary medicine for malaria. Thus, this study was to document the knowledge and the uses of medicinal plants used by the. The reaction mixtures were incubated with 3 mm of hematin, 10. The use of medicinal plants for the treatment of diseases including malaria is commonplace in ghanaian traditional medicine, though the therapeutic claims for most plants remain unvalidated. Medicinal plants are used to treat diseases also where the biodiversity of plants occur in parallel with endemic transmission of malaria. Both compounds were isolated during a drug discovery program aimed at the identification of new antimalarial leads from a prefractionated natural product library. These compounds were mainly isolated from plants of the chloranthus genus, many species of which are named. Antimalarial activity have been shown from different parts of antimalarial medicinal plants species.
Evaluation of the leishmanicidal and antimalarial activity of selected extracts. Antimalarial activity of methanolic extracts from plants used in. Antiplasmodial activity of the aqueous extracts and successively obtained petroleum ether, ethyl acetate and methanol fractions of the whole phyllanthus fraternus plant, the leaves of tectona. In vitro antimalarial activity of medicinal plant extracts against plasmodium falciparum article pdf available in parasitology research 1081. Evaluation of antimalarial activity of a traditionally. International journal of medicinal plants research issn. Pdf herbal plants used for the treatment of malariaa. Plant extracts showed moderate to good antiparasitic effects.
Selected plants being used in indian traditional medicine to treat malaria and malarialike symptoms plant name, family, part used common name method of preparation referencs adhatoda zeylanica medic. Over two hundred medicinal plants have been recorded herein for their use as antimalarials in cameroonian folk medicine and about a hundred active phytochemicals isolated. Antimalarial activity of selected malaysian medicinal plants. Antiplasmodial activity of two medicinal plants against clinical. Moreover, those plants currently used by indigenous people to treat malaria should be documented and investigated as potential sources of new antimalarial drugs. The plant extract did not show any sign of toxicity and mortality at 2000 mgkg. It is inhabited by the ameru, a bantu tribe who are predominantly agararian. Antimalarial action liver hypnozoites weak action against erythrocytic stage of vivax, so used with supressives in radical cure no action against erythrocytic stage of falciparum has gametocidal action and is most effective antimalarial to prevent transmission disease against. While each of the plant extracts has potential to yield useful antimalarial compounds. In vitro and in vivo studies revealed that malaysian medicinal plants, piper sarmentosum, andrographis paniculata and tinospora crispa produced considerable antimalarial effects. The present study was planned to evaluate antiplasmodial activity of two plants azadirachta indica and acacia nilotica regularly used in primary health care and oral hygiene in rural areas of rajasthan, india. Promising antiplasmodial activity was found in the extracts from two plants, phyllanthus emblica. In vitro antimalarial activity and cytotoxicity of. The herbal knowledge of indigenous communities for malaria treatment can play an important role in identification of any new antimalarial plants that is yet to discover.
An illustrated, scientific and medicinal approach appears to be a medical compendium of plants intended as a guide and reference resource for professionals in the field. Chloroform extract in vitro did show better effect than the methanol. Twentyfour 24 albino mice were infected by intraperitoneal injection of standard inoculum of chloroquine sensitive plasmodium berghei nk 65. Antimalarial medicinal plants and their impact on cell populations in various organs of mice. The most frequently used plant parts were leaves 33%, roots 31%, and bark and whole plant 12%. Activity of some species of meliaceae plants and their constituent limonoids.
Pdf antimalarial activities of medicinal plants and. Screening of naturalsynthetic compounds for antimalarial. Alstonia boonei is a high tree of up to 33m, with a straight and. A careful analysis of traditional medicinal knowledge and associated medicinal plants often used to cure malaria could be of great assistance to the global drug discovery programs 12 14. Advancement in phytochemical studies in medicinal plants has really helped in the production of helpful medicinal drugs.
Root aqueous extract of lecaniodiscus cupanioides was evaluated for antimalarial activity and analyzed for its phytochemical constituents. Pdf antimalarial activities of medicinal plants and herbal. Evaluation of antimalarial activity of carissa spinarum linn. Antimalarial activities of some selected traditional herbs. Hplc separation and in vitro antimalarial studies of. In vitro and in vivo antimalarial activity assays of seeds. Kevin spelman, phd malaria, in addition to being the most pernicious parasitic disease of humans, is also the most prevalent. Antimalarial activity of plant extracts was evaluated by the method explained by afshar et al 45 with some modifications. Antimalarial activity of medicinal plants used in traditional. The aim was to corroborate how traditional practices using chewing sticks fresh twigs of. In traditional therapies, the whole plant is therefore rarely used for medicine. Antimalarial activity of extracts of malaysian medicinal. Pdf in vitro antimalarial activity of medicinal plant extracts against.
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